Sandalwood synthetic may be the answer to hair-loss



Sandalwood has always been a skin saint, but hair-loss looks set to benefit from a synthetic version – Sandalore.

Recent research has demonstrated an exciting development for anyone suffering hair-loss or those just wanting a thick, glossy mane.
Sandalwood itself has been used for centuries in luxury skin treatments, to improve wound-healing and stimulate keratinocyte proliferation and turn-over and we use it in our perfumes, elixirs and moisturisers. But there is recent published research which suggests that using a synthetic form of Sandalwood – Sandalore, or, a similar synthetic, Brahmanol, benefits hair growth. In recent research, Sandalore was applied to the scalp to prolong the period of growth in the hair root. (Ralf Paus of Florida University with Manchester University 2018) . There may be more synthetics with similar properties, that could also work, but were not in this trial. (The study was partially sponsored by a company who produce Sandalore, although the science appears to be sound). As we wait for the study to be replicated, the study results seem hopeful.

The hair follicles contain receptors in the root sheath and these were activated when Sandalore was applied. Olfactory receptors are not just in the nose, strange as it may seem, they are all over the skin, even in the gut. It is these receptors, (called OR2AT4, for anyone serious about skin research) which bind to Sandalore. The receptors in hair follicles responded when Sandalore was applied by increasing the follicle’s cycle significantly, whilst also inhibiting the regulation of hair loss by about 25%. So shortening the phase in which hair usually sheds and increasing the growing phase. It is not yet clear whether this could re-awaken hair follicles long gone to hair heaven – but we can be sure that this is furiously being tested. So, everything crossed for a future of full-haired heads for everyone who wants one!


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